Carcinoma de células escamosas de cavidad bucal en un centro de tercer nivel de atención social en la ciudad de México. Experiencia de cinco años / Oral cavity squamous cells carcinoma, 5 years experience in a third

El carcinoma epidermoide o de células escamosas, es una neoplasia maligna que se origina de las células escamosas del epitelio que recubre la mucosa, es la más frecuente de la cavidad bucal. Objetivo: determinar si la supervivencia y muerte de los pacientes con carcinoma epidermoide de cavidad bucal, asociada a la edad, género, factores de riesgo, grado histológico y tratamiento recibido. Método: Se revisaron los archivos del servicio de Anatomía Patológica del Centro Médico Nacional "20 de Noviembre" de 1997 al 2001 (49.615 registros histopatológicos). Sólo 149 con diagnóstico de carcinoma epidermoide en cavidad bucal, y presentaban las variables: edad, género, alcoholismo, tabaquismo, enfermedades de transmisión sexual, ocupación, enfermedades sistémicas, uso de prótesis dental, antecedentes familiares oncológicos, liquen plano bucal; grado de diferenciación histológica, localización, tratamiento, recurrencia, metástasis, supervivencia y muerte; se analizaron los resultados con la prueba de Fisher. Resultados: De los 149 sólo 49 casos contaban con todos los datos, de éstos, la relación hombre-mujer 2:1, localización más frecuente la lengua, grado de diferenciación: 35 casos bien diferenciados (71,4%), 9 moderadamente diferenciados (18,4%) y 5 poco diferenciados (10,2%). Los factores de riesgo, uso de tabaco (65,3%) y alcohol (63,3%); ambas en 55,1%; hipertensión arterial 10,2% y Diabetes Mellitus 26,5%. antecedentes heredofamiliares oncológicos 22,45%. El tratamiento fue la combinación de quimioterapia, cirugía y radioterapia (59,2%). El seguimiento de los pacientes desde un mes hasta 120 meses con una media de 34,85 meses. La recurrencia se presentó en 23 de 49 casos (46,9%). presentaron metástasis 16 pacientes (32,2%). 11 de los 49 murieron (22,45%). Discusión: Las asociaciones más importantes fueron las siguientes: entre la muerte y los antecedentes heredofamiliares oncológicos (p = 0,094) y entre el grado de diferenciación y la recidiva (p = 0,034) con la prueba de Fisher (AU)

Squamous cell carcinoma is the most frequent malignant neoplasm in the oral cavity. Squamous epithelial cells surrounding the oral mucosa are the source of this neoplasm. Objective: To determine if survival and death of patients with oral squamous cell carcinoma are associated with age, gender, risk factors, histological grade and treatment received. Method: Files (49,615) dated from 1997 to 2001 from the Pathology Service in Centro Medico Nacional "20 de Noviembre" were studied. One hundred and forty nine histopathological files out of 49,615 were of oral squamous cell carcinoma. These variables were registered: age, gender, alcoholism, tabaco, sexually transmitted diseases, occupation, systemic diseases, dental prothesis usage, oncological family history, lichen planus, histological differentiation grade, localization, treatment, recurrence, methastasis, survival and death. Results were analyzed with Fisher test. Results: There were 49 cases with complete data, ratio 2:1 men-women, the most frequent localization was tongue. The histological differentiation grade was: 35 well differentiated cases (71.4%), 9 of moderate differentiation (18.4%) and 5 low differentiated (10.2%). Risk factors were tobacco (65.3%), alcohol (63.3%); both tobacco and alcohol (55.1%); high blood pressure (10.2%), Diabetes Mellitus (26.5%) and oncological family history (22.45%). The treatment was the combination of surgery, radiotherapy and chemotherapy (59.2%). Patients’ follow-up was from one month to 120 with an average of 34.85 months. Twenty three out of 49 cases (46.9%) showed recurrence. Sixteen patients (32.2%) showed methastasis. Eleven out of 49 died (22.45%). Discussion: The most important associations were: between death and oncological family history (p = 0.094), as well as between histological grade and recurrence (p = 0.034) (AU)

Ameloblastomas: a regional Latin-American multicentric study.

AIM: To classify 163 ameloblastoma cases according to the new WHO Classification of Odontogenic Tumours (2005) and analyse their clinical and microscopic features. METHODS: We studied the clinico-pathological features of 163 ameloblastoma cases from nine regional Latin-American institutions from Mexico and Guatemala. RESULTS: Ameloblastomas comprised 22.7% of all odontogenic tumours. The mean age was 41.4 years for solid ameloblastoma (SA) and 26.3 years for unicystic ameloblastoma (UA) (P < 0.001) and both sexes were almost equally affected. The mandible was mainly affected for both UA and SA. The mean size was 6.2 cm for SA and 6.3 cm for UA cases. The recurrence rate was 21.7% for SA and 12.6% for UA. UA was twice as more frequent than the solid variant. CONCLUSIONS: In this study we found that UA was frequently misdiagnosed as SA; however, there are enough clinical and microscopic features that allow for an accurate differentiation between both types of ameloblastoma that should be recognized for surgical and prognostic purposes. In this study, SA was not found in patients younger than 20 years, UA had a constant myxoid stroma while mature connective tissue was more frequently associated with the solid type.